Distillation is a critical process in the pharmaceutical industry, especially when it comes to handling heat-sensitive compounds.
Molecular or short path distillation techniques are essential for separating these compounds without causing degradation.
This method is particularly important for organic and silicon compounds that cannot withstand high temperatures.
4 Key Applications of Distillation in the Pharmaceutical Industry
1. Separation of Heat-Sensitive Compounds
Molecular distillation is particularly useful in pharmaceuticals because it allows for the separation of compounds that are sensitive to high temperatures.
Traditional distillation methods often involve temperatures that could degrade these compounds.
Molecular distillation operates under much lower temperatures and higher vacuums, reducing the risk of degradation.
2. Use of High Vacuum Stills
Instead of using traditional distilling towers, this method employs high vacuum stills.
These stills create an environment where the pressure is significantly reduced, allowing for lower boiling points and thus lower temperatures during the distillation process.
This is crucial for maintaining the integrity of heat-sensitive pharmaceutical compounds.
3. Short Path Distillation Setup
The setup for short path distillation involves keeping the distance between the condenser and evaporator very short.
This configuration minimizes the exposure of the compounds to heat and ensures that the vapors travel a short distance.
This helps in maintaining the purity and effectiveness of the compounds.
4. Applications in Pharmaceutical Production
Solvent Swapping
This process is vital in pharmaceutical production, especially when creating medicines that require multiple solvents at different stages of production.
Molecular distillation allows for the careful extraction and replacement of solvents without affecting the temperature and solubility limits of the active pharmaceutical ingredients.
Purification and Crystallization
Distillation is also used for purifying compounds from volatile impurities and for crystallization processes.
These are essential for the final formulation of many drugs.
Formulation of Medicines
Solvents are crucial in the formulation of various medicines.
The controlled use of distillation ensures that these solvents are used effectively and safely.
Equipment Used in Pharmaceutical Distillation
The equipment for molecular distillation in the pharmaceutical industry ranges from pilot-sized units to larger systems capable of handling various feed rates.
These units are equipped with independent vacuum groups, chilling groups, hot oil heating systems, and control cabinets, ensuring precise control over the distillation process.
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