The disadvantages of centrifugal filtration include:
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Complexity and Difficulty in Operation: Centrifugal filtration, particularly in the context of centrifugal molecular distillation, involves complex equipment that requires a high-speed rotating turntable and advanced vacuum sealing technology. This complexity makes both the manufacturing and operation of the equipment challenging.
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Cleaning and Sanitation Issues: Similar to rotary evaporators, centrifugal filtration devices can be difficult to clean and sanitize. This can lead to issues such as cross-contamination, especially when dealing with multiple samples or when bumping occurs.
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Incompatibility with Foaming Samples: Centrifugal filtration is not suitable for samples that tend to foam. Specialized equipment or additives like defoamers are required to handle such samples, which adds to the complexity and cost of the process.
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Sample Deposition on Container Walls: During the filtration process, distilled and concentrated substances may spread on the walls of the containers, which can lead to loss of sample and require additional steps for recovery.
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Limited Observability: Unlike some other filtration techniques, observations cannot be made during the centrifugal filtration process. This lack of real-time monitoring can be a disadvantage, especially in research settings where process adjustments or immediate analysis might be necessary.
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Limited Capacity and Manual Operation: While not directly related to centrifugal filtration, the use of laboratory filter presses in conjunction with centrifugal methods highlights additional limitations such as limited capacity and the need for manual operation, which can be time-consuming and less efficient.
These disadvantages highlight the need for careful consideration of the specific requirements and constraints of the laboratory or industrial setting when choosing to employ centrifugal filtration.
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