Distillation is a crucial process in the pharmaceutical industry.
One example is the use of molecular distillation, also known as short path distillation.
This method is primarily used for separating heat-sensitive compounds without causing degradation.
Molecular distillation is particularly effective for organic and silicon compounds that cannot withstand temperatures above 250ºC.
Molecular Distillation in the Pharmaceutical Industry: 4 Key Applications
Technique and Equipment
Molecular Distillation: This method uses high vacuum stills instead of traditional low-pressure or atmospheric distilling towers.
The high vacuum environment allows for lower distillation temperatures, preventing thermal degradation of sensitive compounds.
Short Path Distillation: Characterized by a short distance between the condenser and evaporator, this setup minimizes the exposure of compounds to heat and prevents their disintegration.
The equipment includes independent vacuum groups, chilling groups, hot oil heating systems, and control cabinets, suitable for various scales from pilot to industrial.
Applications
Solvent Swapping: This process involves the careful extraction of one solvent and its replacement with another, crucial in the synthesis of pharmaceutical ingredients.
It ensures that the active ingredients maintain their temperature and solubility limits, essential for the stability and efficacy of medicines.
Compound Separation and Purification: Molecular distillation is used to separate and purify chemical compounds, including those used in the production of antibiotics like penicillin, analgesics like aspirin, and various topical medications.
Crystallization and Removal of Impurities: The technique aids in the crystallization process and the removal of volatile impurities, enhancing the purity and quality of pharmaceutical products.
Specific Uses in Pharmaceutical Production
Formulation of Medicines: Solvents are critical in the formulation of diverse medicines, and molecular distillation ensures their safe and effective use.
Concentration of Solutions: The method is also used to create concentrated pharmaceutical solutions by adding compounds or solvents to active ingredients.
Upgrading Substances: It plays a role in upgrading pharmaceutical substances for artificial feeding and in the blending of ingredients for creams, ointments, and lotions.
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