There are different types of milling in the pharmaceutical industry, each with its own mechanism of action and suitable materials. Here are some types of milling in pharma:
1. Impact Milling: This type of milling involves the use of a hammer mill. It is suitable for brittle and dry materials.
2. Shear Milling: Shear milling is achieved using an extruder and hand screen. It is commonly used for deagglomeration and wet granulation.
3. Attrition Milling: Oscillating granulators are used for this type of milling. It is primarily used for dried granulation.
4. Shear Compression Milling: Conical screening mills are used for shear compression milling. It is suitable for wet and dry granulation.
In addition to these specific types of milling, there are also various types of grinding mills used in the pharmaceutical industry. Some examples include:
- Laboratory Sample Mill: Designed for grinding extra hard dry materials.
- Laboratory Cutting Mill
- Laboratory Disk Mill
- Laboratory Centrifugal Mill
- Laboratory Knife Mill
- Laboratory Ball Mill
Pharmaceutical companies often micronize active pharmaceutical ingredients to improve blending in pills, tablets, or liquid formulations, and to alter how the drug is absorbed. Particle reduction of raw materials is also used to create suspensions and solutions in pharmaceutical formulation and nanotechnology.
Jet milling is another type of milling commonly used in the pharmaceutical industry, especially for finely ground active substances and excipients. It is highly effective in reducing particle size and is used for drug products where particle size is relevant to effective delivery.
Overall, milling and grinding play a crucial role in the pharmaceutical industry, whether it is for manufacturing products, quality control, or preparing samples for analysis. Engineers continue to research and improve the understanding of the grinding and milling process.
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