Knowledge What is the recommended temperature for storing proteins? -70°C for Optimal Stability
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Tech Team · Kintek Solution

Updated 1 day ago

What is the recommended temperature for storing proteins? -70°C for Optimal Stability

The recommended temperature for storing proteins, according to peer-reviewed studies, is -70°C, which has been shown to maintain protein activity effectively for at least one year. While lower temperatures like -196°C (liquid nitrogen) are sometimes used, research indicates they are unnecessary for typical protein storage needs, as -70°C provides sufficient stability without the added complexity or cost of ultra-low temperature storage.

Key Points Explained:

  1. Optimal Storage Temperature (-70°C)

    • Studies confirm that -70°C is sufficient to preserve protein structure and function for extended periods (at least one year).
    • This temperature prevents protein degradation, aggregation, and enzymatic activity loss, which are common at higher storage temperatures.
  2. Comparison with Ultra-Low Temperatures (-196°C)

    • While liquid nitrogen (-196°C) is sometimes used for long-term storage, research suggests it is not required for most protein stability needs.
    • The marginal benefits of -196°C do not justify the increased logistical challenges, costs, and risks (e.g., sample handling hazards).
  3. Practical Considerations for Protein Storage

    • Freezer Stability: -70°C freezers are widely available and more practical than liquid nitrogen systems for most labs.
    • Sample Protection: Proper sealing (e.g., cryovials) and avoiding freeze-thaw cycles are equally critical for maintaining protein integrity.
  4. Exceptions & Special Cases

    • Some highly unstable proteins or long-term archival storage (decades) may still benefit from -196°C, but this is not the norm.
    • Always refer to specific protein stability data when available, as optimal conditions can vary by protein type.

For most researchers, -70°C strikes the best balance between efficacy, convenience, and cost—making it the recommended choice for routine protein storage.

Summary Table:

Key Consideration Details
Optimal Temperature -70°C preserves protein structure & function for at least one year.
vs. Ultra-Low (-196°C) No significant benefit for most proteins; higher cost & handling risks.
Practicality -70°C freezers are widely accessible and easier to maintain.
Critical Practices Use cryovials, avoid freeze-thaw cycles, and follow protein-specific data.

Ensure your protein samples remain stable and active with the right storage solutions. KINTEK provides reliable lab equipment to meet your research needs. Contact us today to discuss your protein storage requirements and explore our range of lab freezers and consumables.

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