To press pills, one typically uses a tablet press, which is a machine designed to compress powder into tablets of uniform shape and size. The process involves the following steps:
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Powder Loading: The powder, which contains the active pharmaceutical ingredient and other excipients, is loaded into a die cavity in the tablet press.
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Compression: The tablet press uses two punches (an upper and a lower punch) that strike together in the die. This action compresses the powder under high force, causing the granulated material to bond and form a hard tablet. The compression is typically achieved through a hydraulic mechanism, where unreduced pressure is applied uniformly in all directions through static liquid.
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Ejection: After compression, the lower punch raises, ejecting the formed tablet out of the die.
The use of a tablet press ensures that each tablet produced is consistent in terms of weight, size, and content uniformity, which is crucial for pharmaceutical applications. The evolution of tablet presses has been driven by increasing demand for tablets, advancements in technology, and the need to comply with stringent regulations such as CGMP (Current Good Manufacturing Process).
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